Product Range: 
  • Specifications:

    We offer Ultrasonicator instruments and software capable of meeting your needs. Covaris Focused-ultrasonicators are engineered to meet your sample preparation needs by delivering highly controlled and focused acoustic energy to your samples. Focused-ultrasonicators standardize sample prep for a variety of application areas including DNA shearing for Next-Gen sequencing, RNA and protein extraction, Chromatin shearing, cell lysis, tissue to biomarker, compound management, formulations, and more.

    Covaris Focused-ultrasonicator software and instruments are designed to work exclusively with Covaris consumables.



    The M220 Focused-ultrasonicator™ is designed for Next-Gen Sequencing applications requiring fragment sizes between 150bp and 5kb. Compact size and ease-of-use make the M220 Focused-ultrasonicator the ideal DNA shearing solution for MiSeq™ and PGM™ users.


    The M220 runs a variety of DNA shearing protocols with Covaris SonoLab 7 software and uses both the Covaris microTUBE & miniTUBE.


    Integrated temperature control within the M220 eliminates the need for an external chiller, saving space and cost.


    The ME220 Focused-ultrasonicator is the multi-sample, multi-application benchtop sample preparation solution for every lab.

    Compact, easy-to-use system formatted for 1 to 8 sample batch-processing- recommend use with microTUBE-50. Accurate, reproducible, and robust sample preparation powered by AFA-energetics. Integrated chiller and automated water management. Less than 2-minute start-up time.





    The S220 Focused-ultrasonicator is a versatile, high power system engineered for pre-analytical sample processing with Covaris’ patented Adaptive Focused Acoustics® (AFA®). Utilizing a spherical acoustic transducer, specifically designed AFA Tubes, and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 15 μl to 18 ml.


    The S220 Focused-ultrasonicator is computer controlled by SonoLab™ Software, incorporating preset protocols for standard methods, such as DNA shearing to specific fragment lengths, and easy-to-use-tools for user-defined protocols. The S220 is also compatible with ActiveX control if required for more specialized customer-defined, laboratory automation applications.


    Focused-ultrasonicators with AFA Technology operate at high frequencies (500KHz) and, therefore, unlike traditional low frequency laboratory sonicators. AFA does not require sound-proof boxes, hearing protectors, or other unusual precautions for their operation.


    The S220 Focused-ultrasonicator is available in higher power (S220X) and robotic capable (S220R) configurations.




    The E220evolution enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes and may be programmed to process from 1 to 8 samples in a single batch. And, when workload increases, the E220evolution can be upgraded to an E220 capable of processing 1 to 96 samples/run or to an LE220 for high throughput processing without purchasing a new instrument.


    The E220 enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes. The E220 may be programmed to process from 1 to 96 samples in a single batch. For example, with 96 samples, 96 different AFA energies may be pre-programmed. With the available racks, the E220 instrument is easily configured for use with all AFA Tubes (volumes from 50µl to 10ml) including single AFA microTUBE™ and the AFA 96 microTUBE Plate, for both single and batch sample processing. The E220 can be operated as a stand-alone unit, or easily integrated as part of an automated laboratory system.


    Focused-ultrasonicators operate at frequencies well beyond the range of human hearing (500KHz) so, unlike traditional (low frequency) laboratory sonicators do not require sound-proof boxes or other special precautions.


    The E220 is also available in higher power (E220X) and robotic capable (E220R) configurations.




    The LE220-plus Focused-ultrasonicator is a scalable, automated, high-performance sample preparation system powered by Adaptive Focused Acoustics® (AFA®) technology, with 1 to 8 tubes at a time parallel processing; 96 tube capacity.


    Features include:

    • Automated water works optimizes

    user-to-user reproducibility

    • Remote set-up and scheduling

    maximizes laboratory efficiency

    • Designed for integration with high-throughput laboratory automation

    with automated water works system


    The LE220-plus system includes control connections to both the AFA ultraCUBE water chiller and the water conditioning module. Significant improvements to laboratory efficiency are enabled with our latest SonoLab software which features a simple, intuitive interface along with a module for remote start-up and daily scheduling.



    As the highest power and fastest sample processing system in the Covaris portfolio, the LE220Rsc rapidly delivers AFA-energetics® to

    standard SBS format plates using the scanning mode. It offers tunable acoustic energy, integration with robotic platforms, and more power than the LE220-plus and R230 Focused-ultrasonicators. This instrument enables a variety of novel high power, fast process applications such as lysis of difficult to lyse microorganisms (for example, yeast) in the 96 AFA-TUBE TPX plate and dissolution of difficult to solubilize compounds.


    The LE220Rsc Focused-ultrasonicator aids in the movement of samples through numerous steps in a workflow on multiple instruments without human intervention. Processing time for a 96 and 384 plate ranges from 5 to 16 minutes, depending on desired fragment size. Multiple isothermal energy delivering modes including scanning mode rapidly delivering AFA-energetics. Enables automated workflows with full robotic integration.




    The R230 Focused-ultrasonicator is the next generation AFA powered instrument, and the first of the R-Series.


    Revolutionize Sample Preparation on Liquid Handlers with On-deck AFA®


    Advantages of the new instrument include:


    • The R230 can be fully integrated on many liquid handler platforms
    • Unique, high-throughput sample processing with AFA-energetics and AFA-TUBE® TPX Plates
    • Proprietary scanning process enabling batch treatment in 96, 384 and 1536 formats
    • Scanning process delivers tunable energy to sample


  • Specifications:

    Covaris tissue disruption systems have been designed to simplify tissue processing workflows. Tissues are collected, flash frozen in liquid nitrogen, pulverized in a cryoPREP Dry Impactor, and then transferred to a Covaris tube for extraction powered by AFA®. The tissueTUBE™ is used to process tissues and extract biomolecules from a wide range of masses for downstream analyses including next-generation sequencing (NGS), qPCR, Microarrays, Mass Spectrometry (MS), GC-MS, NMR, and other detection methods.

    1. Increases yields with an integrated and rapid workflow
    2. Preserves stable and labile molecules
    3. Maintains samples at cryogenic temperatures
    4. Eliminates clean-up and risk of contamination with single-use tissueTUBE      

  • Specifications:

    1. truXTRAC FFPE kits

    • Superior extraction for low mass inputs from slides and cores
    • Hands-free paraffin removal – no organic solvents required
    • Extract longer RNA with high DV200 scores – detect rare fusion events
    • Reduced variability with a simplified and standardized workflow
    • Automated, high throughput processing available

    2. truChIP kits

    The truChIP® Chromatin Shearing Kits were designed and optimized for the efficient and reproducible shearing of chromatin from cultured mammalian cells (suspension or adherent, FFPE, clinically archived tissues, and tissues (20 to 120 mg) using the Covaris Adaptive Focused Acoustics® (AFA®) technology.

    3. truXTRAC cfDNA kits

    This sample extraction kit is an active AFA-based, high-throughput, high-yield system designed to standardize circulating cell-free DNA extraction.

    • Extract higher complexity cfDNA to unlock the true biology of the sample
    • Higher cfDNA yields and quality with Active Extraction
    • Reduced extraction bias – cfDNA profile in the original plasma sample is reflected in the extracted and purified sample
    • Reduced variability with standardized cfDNA extraction
    • Simplified workflow with automated purification capability enables high throughput processing

    4. truCOLLECT

    Whole blood dry-stabilization and transport solution.

    • Extract more than 1 µg of DNA from 80 µL dry-stabilized whole blood
    • Reduce costs and logistical shipping challenges with ambient collection, shipping, and storage
    • Active drying preserves sample integrity and maintains the true biology of the sample
    • Easy sample loading and tracking – 2D barcoding provides sample traceability
    • High throughput extraction capability with bead-based purification


    5. Cell Lysis and Protein Extraction Buffers

    A range of extraction buffers for the efficient protein extraction from cells and tissues optimized for your downstream application.

  • Specifications:
    1. microTUBES

    2. miniTUBES

    3. g-TUBEs
Brand Category: 
The Covaris business was built upon its team’s in-depth knowledge ranging from acoustic physics, mechanical engineering to biophysics and molecular biology. At Covaris, their mission is to leverage their enabling technology to provide sample preparation instruments and solutions to the analytical and life sciences industry. The Covaris technology foundation is its proprietary and patented Adaptive Focused Acoustics™ (AFA) technology. The Covaris AFA technology enables numerous non-contact, isothermal processes to be developed, for use in a broad range of applications in both biology and chemistry, including Genomics, Proteomics, and Drug Discovery research. In many cases, the ability to impart both thermal and non-contact control of application processes could not be obtained prior to the development AFA technology. This gives Covaris truly unique competitive advantages, which translates into fast adaptation of Covaris technology by customers, as well as rapid business growth. Which system to select? Covaris offers a family of instruments for effective sample preparations. Covaris systems may be configured in many formats, but we recommend following a few simple steps to reach the right product quickly: Step 1: If your starting biological material is hard to process tissues, such as bone, muscle, skin, cornea, seed, leaf, please select CryoPrep for effective tissue disruption and homogenization. For softer tissues, such as liver, brain, or cell culture and biological samples in solution, there's no need to use CryoPrep, proceed to step 2. Step 2: If sample processing temperature needs to be below -20°C for labile target molecules, please select Covaris S-series. Step 3: If sample preparation temperature can go above 4°C, please select Covaris S-series for single tube processing, or select E-series or L-series for high throughput processing. If DNA shearing is your primary application, the S2 is the instrument of choice. Check out the Broad Applications of Covaris AFA technology