Sphere Fluidics

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  • Specifications:

    The next generation single cell analysis system for antibody discovery and cell line development.

    Current processes for finding novel antibody targets or developing stable cell lines are time consuming and inefficient. Whether you are screening whole B cell repertoires, hybridomas, CHO or other cells, approaches such as cell sorting, clone picking or limiting dilutions have their associated drawbacks – some do not allow cell secretion assays, some tend to be harsh on the individual cells impacting cell viability and outgrowth. Existing approaches are suboptimal, costly, require various individual steps, therefore potentially introducing human error and contamination.

    Cyto-Mine® is the new generation solution which allows you to accelerate, automate and simplify your antibody discovery and cell line development workflows.

    Targeted Discovery. Rapidly identify and isolate your rare cells of interest.
    Monoclonality Assurance. Extensive proof of monoclonality for cell line development.
    Significantly Reduce Timelines and Costs. Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
    Flexibility. Flexible assay design allows quantitative measurement of antibody secretion.
    Sterility. The entire process is automated, sterile, and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.


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Founded in 2010, Sphere Fluidics is an established Life Sciences company, originally spun out from the University of Cambridge. We’ve already developed 25 patented products – biochips and specialist chemicals – which are assisting over 220 customers globally with their research. For the last 4 years we have been developing Cyto-Mine®. Cyto-Mine® is the world’s first The Single Cell Analysis & Monoclonality Assurance System. It is the next generation platform that will transform biopharmaceutical discovery and cell line development workflows. It is specifically designed to automatically perform: high-throughput single cell encapsulation, incubation then protein secretion assays, rapid cell sorting, dispensing of ‘hit’ single cells into individual wells of 96- or 384-well MTPs and imaging / monoclonality verification.