Immulogy for COVID-19

 

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 Novel Coronavirus (2019-nCoV), is a positive-sense, single-stranded RNA virus that can cause COVID-19 disease, a lethal respiratory disease. This new virus belongs to the genus Betacoronavirus, which also includes SARS-CoV and MERS-CoV.

Recent paper by Hoffmann et al. confirm findings reported by Zhou et al. that angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for SARS-CoV-2, as it is for SARS-CoV (1, 2). In addition, they identify the serine protease TMPRSS2 as a critical factor in the priming of the SARS-CoV-2 spike (S) protein, an essential step for viral entry into host cells through fusion of the viral and cellular membranes. This work expands our knowledge of key factors involved in SARS-CoV-2’s entry into cells and reveals some promising avenues for SARS-CoV-2-directed therapies.

 

SARS-CoV-2 Antibody validated by virus infected cell lysates

GeneTex is proud to offer an extensive line of research antibodies and proteins to support the study of SARS-CoV-2, several of which were validated using virus-infected cell lysates. 

SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604)

SARS-CoV / SARS-CoV-2 (COVID-19) nucleocapsid antibody [6H3] (GTX632269)

ACE2 antibody [N1N2],
N-term (GTX101395)

     

SARS-CoV-2 (COVID-19)
spike antibody (GTX135356)

SARS-CoV-2 (COVID-19)
nucleocapsid antibody (GTX135357)
SARS-CoV / SARS-CoV-2 (COVID-19) ORF7a antibody [3C9] (GTX632602)
     
 
SARS-CoV / SARS-CoV-2 (COVID-19) NSP8 antibody [5A10] (GTX632696) TMPRSS2 antibody [N2C3] (GTX100743)  
   
SARS-CoV-2 (COVID-19) nucleocapsid protein (GTX135357-pro)    

 

Click here to view the range of antibodies for SARS-Cov-2. 

 

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COVID-19 Human IgM/IgG Rapid Test

COVID-19 Human IgM/IgG Rapid Test for Professional Use

This product is a lateral flow immunoassay for the rapid detection of human IgM and IgG antibodies against COVID-19 virus in human whole blood, plasma, or serum.

Advantages

  • Fast, convenient, reliable
  • Results in 15 minutes
  • Regulatory Status: GMP grade; Emergency Use Authorization (EUA) submission to FDA.

For more information: http://www.abnova.com/products/products_detail.asp?catalog_id=DC0301

 
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COVID-19 Human IgM IgG Assay Kit for Research Use

COVID-19 Human IgM IgG Assay Kit is an indirect enzyme-linked immunoassay (ELISA) for detection of human IgM and IgG antibodies against COVID-19 virus in human serum.

Kit content:

  1. 96-Well COVID-19 Spike Protein Coated Microplate
  2. Anti-human IgM antibody (HRP)
  3. Anti-human IgG antibody (HRP)

For detail information: http://www.abnova.com/products/products_detail.asp?catalog_id=KA5826

Product Cat No. Packaging
COVID-19 Human IgM/IgG Rapid Test for Professional Use DC0301 20 tests
COVID-19 Human IgM IgG Assay Kit for Research Use KA5826 96-well

 

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Reagents for Serology Testing

Although molecular diagnostics have served as the current standard for COVID-19 screening assays, serology antibody testing is deployed for surveillance and investigational purposes. Since antibodies continue to circulate after an infection has cleared, serology tests can misdiagnose individuals who have previously been infected and have since recovered.

Serologic tests are an important tool for monitoring the evolution of an outbreak. Specifically IgG/IgM antibody tests are essential for identifying previously undiagnosed infections in the asymptomatic population. Meridian has just released new high-performing SAR-CoV-2 antigens for the development of COVID-19 IgG/IgM serology assays. The recombinant antigens are expressed in human mammalian cells and insect cells using proprietary expression and purification technologies. Expression in either human or insect cells provides for post-translational modifications such as glycosylation and phosphorylation which can offer significant performance advantages over E. coli expressed formats.

SARS-CoV-2 Recombinant Antigens

Product Expression System Cat. No.

Spike protein, S1 Subunit, His-tag  

Insect-Cell 9556
Spike Protein, N-terminal Domain (NTD) S1 Subunit, His-tag Insect-Cell 9557
Spike Protein, Receptor Binding Domain (RBD) S1 Subunit, His-tag  Insect-Cell 9558
Spike Protein, S2 Subunit, His-tag  Insect-Cell 9559
Nucleocapsid Protein, His-tag Insect Insect-Cell 9560
Spike Protein, Receptor Binding Domain (RBD) S1 Subunit, His-tag  HEK293 9552
Spike Protein, S1 Subunit, His-tag HEK293 9553
Nucleocapsid Protein, DYKDDDDK tag  HEK293 9554